Circulating microRNA-133a and its associations with left ventricular hypertrophy in men with arterial hypertension

Abstract Introduction Arterial hypertension (AH) is the most common cardiovascular (CV) diseases and one of major a risk factor for CV complications mortality. An important reason development progression number are epigenetic factors regulating gene expression, which include microRNAs. MicroRNA-133a epigenetics factor, has cardioprotective properties, but its role in left ventricular hypertrophy (LVH) patients with AH, including men, not well understood. Purpose The aim study was to investigate circulating microRNA-133a levels, associations (LV) parameters LVH men AH. Methods In included 57 AH grades 2–3 aged 43 64. main group consists 32 comparison 25 without LVH. groups were comparable age duration hypertension. control consisted 22 practically healthy age. determined according 2018 ESC/ESH guidelines. Circulating plasma levels obtained by polymerase chain reaction using CFX96 Touch System, “TaqMan microRNA Assay” “TaqMan® Universal PCR Master Mix” reagent kits. Results (total group) significantly lower than (0.212 [0.091; 0.364]) vs (0.402 [0.178; 0.513]), p<0.05). (0.125 [0.078; 0.295] 0.276 [0.126; 0.397], p<0.05 0.402 (men LVH) there statistically significant negative correlation between LV mass index (R=−0.42, p<0.01) no ejection fraction or E/e' (averaged) ratio (p>0.05). (without Conclusion results may indicate decreased pathogenesis Funding Acknowledgement Type funding sources: None.